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Ketamine is a medication originally developed as a surgical anesthetic, but it has gained popularity in psychiatry for its rapid-acting antidepressant effects. It works by blocking the N-methyl-D-aspartate (NMDA) receptor in the brain, which helps alleviate symptoms of depression and other mental health conditions. Ketamine is particularly effective for treatment-resistant depression, suicidal thinking, and trauma symptoms where traditional antidepressants have failed. Esketamine, a version of ketamine, is FDA-approved for use as a nasal spray under the brand name Spravato. It is indicated for adults with treatment-resistant depression and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior.
Treatment starts with a comprehensive evaluation. Patients receive esketamine (Spravato) as a nasal spray, administered under the direct supervision of a healthcare provider. Each treatment session lasts about two hours, during which patients are monitored. Initially there are twice-weekly sessions, gradually transitioning to weekly or bi-weekly sessions based on response and progress. There are typically a total of 14 sessions over 12 weeks. This approach allows for real-time adjustments to the treatment plan, ensuring that each patient receives personalized care tailored to their unique need.
Unlike traditional antidepressants, esketamine can work quickly, often providing noticeable improvements within hours or days. This rapid effectiveness is particularly valuable for individuals who have not responded to other treatments. By integrating this innovative treatment into our practice, it aligns with our commitment to accessing and utilizing all available resources to improve the lives of the communities we serve. Additionally, we have chosen to use Spravato, the FDA-approved nasal spray form of esketamine, rather than intravenous (IV) ketamin
You attend your scheduled appointment. Estketamine spray is administered. You lay down on a couch in a comfortable environment for some time to allow the treatment take effect.
Ketamine is a two-hour treatment at Carencia, administered as a nasal spray. Its impact is often felt immediately and within 40 minutes, patients typically feel a marked difference in their depression symptoms. The treatment is often effective for up to 16 weeks, so we will typically create a treatment routine with frequent evaluations for you.
While Ketamine is not a first-choice treatment for depression at Carencia, we do cautiously consider it when other treatments come up short. Specifically, we use it for what is called treatment-resistant depression or TRF, which is a severe depression that has held up against other therapies.
Ketamine is broadly considered safe, but for those who have a history of psychosis, schizophrenia, or substance abuse as well as teenagers, those pregnant or breastfeeding, or older adults with dementia, Ketamine should be avoided or used with outsized caution.
